The website of the Oregon-California Trails Association is a great resource for finding hotels in Hannibal, MO. Whether you are looking for a place to stay while seeing the sites along the Oregon and California Trails, or if you're simply visiting the other great historic sites in our nation, finding information about Hannibal travel has never been easier!

To use this page to reserve your Hannibal hotel room you can either click on the hotel name for more information or use the search box to your left to get live rates for all hotels in Hannibal. Clicking on the hotel name will give you more detailed information about that specific hotel such as amenities, photos and nearby attractions. If you want to see which Hannibal hotels have availability for the dates you will be traveling, please enter the dates into the search box to the left to pull back for a list of hotels that have those dates open and their rates.

United States  :  Missouri  :  Hannibal

Hannibal, MO Hotels

Quality Inn & Suites
120 Lindsey Drive
Hannibal, MO 63401
Nightly Rates: ( 91.99 - 91.99 )
2 Star
Full Service hotel featuring 94 luxurious oversized rooms and 2 room suites, conference center, Quality Beginnings Full Hot breakfast and for great food and fun enjoy Fiddlestiks restaurant on the premises. Hotel offers a tropical indoor re...more

Hannibal Super 8 Motel
120 Huckleberry Heights Dr.
Hannibal, MO 63401
Nightly Rates: ( 56.88 - 64.88 )
2 Star
The Super 8 Motel Hannibal, Missouri is located off Hwy 61 and is minutes away from Quincy, Illinois and St. Louis, Missouri. This Super 8 is minutes away from Mark Twain Historic District, Boyhood home of Samuel Clemens (Mark Twain) ...more

Hannibal Travelodge
500 Mark Twain Ave.
Hannibal, MO 63401
Nightly Rates: ( 42.75 - 55.00 )
2 Star
FREE CONTINENTAL BREAKFAST EXPANDED CABLE TV W/ HBO HIGH SPEED WIRELESS INTERNET IN SOME ROOMS KITCHENETTE ROOMS AVAILABLE POOL SIDE ROOMS AVAILABLE FREE LOCAL PHONE CALLS GUEST LAUNDRY <p> <b>LOCAL ATTRACTIONS:</b> ...more

Holiday Inn Express Hotel & Suites Hannibal, Missouri
4000 Market St.
Hannibal, MO 63401
Nightly Rates: ( 75.00 - 99.50 )
3 Star
Welcome to the newly renovated Holiday Inn Express Hotel & Suites located near Highway 61 in America's Hometown, Hannibal, Missouri. Conveniently located near General Mills, Buckhorn, Enduro, and all other factories located in industrial ar...more

Comfort Inn Hannibal
123 Huckleberry Dr.
Hannibal, MO 63401
Nightly Rates: ( 69.99 - 69.99 )
3 Star
WIRELESS INTERNET ACCESS IN ALL ROOMS! Historical location of Mark Twain's boyhood home. ...more

Econo Lodge Hannibal
3604 McMasters Ave.
Hannibal, MO 63401
Nightly Rates: ( 49.50 - 77.00 )
2 Star
The Econo Lodge in Hannibal is located in the heart of the city and is adjacent to I-72 and HWY 61. Mark Twain historical sites within minutes. The hotel features a complimentary Continental Breakfast. Several restaurants within a 5 minute ...more

Hannibal-Days Inn
4070 Market Street
Hannibal, MO 63401
Nightly Rates: ( 50.00 - 65.99 )
3 Star
The Days Inn Hannibal, MO would like to invite you to come and experience the adventures of Tom and Huck in America's Hometown. The Days Inn Hannibal is located at the junction of Highway 61 and 61 Business Route. We are located just minute...more